Here are a few case studies of collaborative chemical synthesis projects that Endeavour has participated in recently.
Treatt is a leading ingredients manufacturer and solutions provider to the global flavour, fragrance and consumer goods market. They have been a strategic partner of Endeavour for many years, exclusively distributing our aroma product range, as well as offering guidance with regard to new product development and market demand.
This relationship has helped us develop an extensive portfolio of high impact aroma products that work well in many applications. These ingredients enable formulators and manufacturers to deliver authentic aromatic profiles – a powerful resource for those looking to create a ‘signature’ product.
Specifically, Endeavour has been able to supply Treatt with challenging natural isolates (e.g. p-mentha-8-thiol-3-one) as well as using our in-house knowledge to provide high-impact compounds such as 4-vinylguaiacol or 3-methyl-2,4-nonanedione – a material Treatt discovered in their black tea Treattarome, a ‘from the named food’ aqueous distillate of black tea.
Having worked with Treatt for more than 20 years, we are looking forward to furthering this relationship in the future.
Oxford Biotrans is a University of Oxford spin-out company developing enzymatic process technologies that yield high-value chemical compounds. Endeavour worked with Oxford Biotrans to determine whether their novel, custom-designed cytochrome P450 enzymes are able to produce the ‘peppery’ sesquiterpine Rotundone (FEMA No. 4867) from a sustainable, natural source.
(-)-Rotundone, ((3S,5R,8S)-3,8-Dimethyl-5-prop-1-en-2-yl-3,4,5,6,7,8-hexahydro-2H-azulen-1-one) is an important odour active constituent of various wines that exhibit peppery spicy notes. It also is reported as being important to oak-aged spirits. In 2008, the aroma detection threshold for rotundone was determined by Wood et al., with the best estimated threshold of 16 ng/L in red wine and 8 ng/L= 0.008 ppb in water.
The Flexolighting programme focused on research and innovations in materials, processes and device technology for OLED lighting, with the intention of building a supply chain within Europe. The aim was to realise OLED devices over a large area/surface with high brightness, high uniformity and long lifetime.
The three-year Flexolighting project (2015-2018) revealed that by introducing novel manufacturing techniques and rethinking the complete supply chain, it is possible to reduce the cost of producing thin, high-efficiency OLED lighting panels to a similar level to that of traditional LEDs.
By introducing a number of innovative new techniques, such as printing some of the OLED’s layers onto flexible steel rather than the more traditional glass, and using a newly developed light extraction film to double the OLED’s illumination, the consortium achieved a potential cost of Euro 1.20 per 100 lumens – a 92% reduction in cost.
Partners of the Flexolighting project included: Brunel University, Tata Steel, Novalia Ltd, Intrinsiq, Aixtron SE, Beneq Oy, Marks and Spencer. This project was supported by: EU H2020.